Publications

Adams

Thu, 23 Apr 2009 19:25:07 -0700

Kim, Y.-J., Zitnan, D., Galizia, C.G., Cho, K.-H., and Adams, M. E. 2006. A Command Chemical Triggers an Innate Behavior by Sequential Activation of Multiple Peptidergic Ensembles. Current Biol. 16: 1395-1407.   Moore, E.L., Haspel, G. Libersat, F. and Adams, M.E. 2006. Parasitoid Wasp Sting: A Cocktail of GABA, Taurine and B-alanine opens chloride channels for central synaptic block and transient paralysis of a cockroach host. J. Neurobiol. 66: 811-820.   Park, Y. and Adams, M.E. 2005. Insect G Protein-coupled receptors: Recent discoveries and Implications. In: Comprehensive Insect Biochemistry, Physiology, Pharmacology and Molecular Biology, (L. I. Gilber, K. Iatrou, and S.S. Gill, Eds.), Elsevier Press, London, Vol. 5, pp. 143-171.   Zitnan, D. and Adams, M.E. 2005. Neuroendocrine Regulation of Insect Ecdysis. In: Comprehensive Insect Biochemistry, Physiology, Pharmacology, and Molecular Biology, (L.I. Gilber, K. Iatrou and S.S. Gill, Eds.), Elsevier Press, London, Vol. 3, pp. 1-60.   Adams, M.E. 2004. Agatoxines. Toxicon 43: 509-525.   Kim, Y., Spalovska-Valachova, I., Cho, K., Zitnanova, I., Park, Y., Adams, M.E. and Zitnan, D. 2004. Corazonin Receptor Signaling in Ecdysis Initiation, Proc. Natl. Acad. Sci. USA 101: 6704-6709.   Park, Y., Y. J. Kim, V. Dupriez, and M.E. Admas. 2003. Two Subtypes of Ecdysis-triggering Hormone Receptor in Drosophila melanogaster. Biol. Chem. 278: 17710-5.   Zitnan, D., I. Zitnanova, I. Spalovska, P. Takac, Y. Park and M.E. Adams. 2003. Conservation of ecdysis-triggering hormone signalling in insects. J. Exp. Biol. 206: 1275-89.   Zitnan, D., L. Hollar, I. Spalovska, P. Takac, I. Zitnanova, S.S. Gill and M.E. Adams. 2002. Molecular cloning and function of ecdysis-triggering hormones in the silkworm Bombyx mori. J. Exp. Biol. 205: 3459-3473.   Park, Y., Y.J. Kim and M.E. Adams. 2002. identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc. Natl. Acad. Sci. U S A 12:12.   Park, Y., V. Filippov, S.S. Gill and M.E. Adams. 2002. Deletion of the ecdysis-triggering hormone gene leads to lethal ecdysis deficiency. Development 129: 493-503.   Zitnanova, I., M.E. Adams, and D. Zitnan. 2001. Dual ecdysteroid action on epitracheal glands and the central nervous system preceding ecdysis of Manduca sexta. J. Exp. Biol. 204: 3483-3495.   Kingan, T.G., R.A. Cardullo and M.E. Adams. 2001. Signal transduction in eclosion hormone-induced secretion of ecdysis-triggering hormone. J. Biol. Chem. 276: 24135-24142.   Zhao, Y., Y. Park and M.E. Adams. 2000. Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel. Biochem. Biophys. Res. Comm. 278: 516-521.   Zitnan, D. and M. E. Adams. 2000. Excitatory and inhibitory roles of central ganglia in initiation of the ecdysis behavioral sequence. J. Exp. Biol. 203: 1329-1340.   Lee, D., M. Gurevitz and M. E. Adams. 2000. Modification of synaptic transmission and sodium channel inactivation by the insect-selective scorpion toxin LqhalphaIT. J. Neurophysiol. 83(3): 1181-7.   Kingan, T. G. and M. E. Adams. 2000. Ecdysteroids regulate secretory competence in Inka cells. J. Exp. Biol. 203(19): 3011-3018.   Yan, L. and M. E. Adams. 2000. The spider toxin omega-Aga IIIA defines a high affinity site on neuronal high voltage-activated calcium channels. J. Biol. Chem. 275(28): 21309-16.   Lee, D. and M. E. Adams. 2000. Sodium channels in central neurons of the tobacco hornworm, Heliothis virescens: Basic properties and modification by scorpion toxins. J. Insect Physiol. 46: (4): 499-508.   Zitnan, D. and M. E. Adams. 2000. Excitatory and inhibitory roles of central ganglia in initiation of the ecdysis behavioral sequence. J. Exp. Biol. 203: 1329-1340.   Zitnan, D., L. S. Ross, I. Zitnanova, J. L. Hermesman, S. S. Gill and M. E. Adams. 1999. Steroid induction of a peptide hormone gene leads to orchestration of a defined behavioral sequence. Neuron 23(3): 523-535.   Lee, D., Y. Park, T. M. Brown, and M. E. Adams. 1999. Altered properties of neuronal sodium channels associated with genetic resistance to pyrethroids. Molecular Pharmacology 55(3): 584-93.

Carson

Thu, 23 Apr 2009 18:26:45 -0700

Differential gene expression in LPS/IFN activated microglia and macrophages: in vitro versus in vivo
Schmid CD, Melchior B, Masek K, Puntambekar SS, Danielson PE, Lo DD, Sutcliffe JG, Carson MJ. 2009 J Neurochem 109 (S1): 117-125.
http://www3.interscience.wiley.com/journal/122309825/issue Published Online: Apr 7 2009 12:31PM DOI: 10.1111/j.1471-4159.2009.05984.x

Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta.
Ploix C, Zuberi RI, Liu FT, Carson MJ, Lo DD.
Int J Med Sci. 2009;6(2):85-92. Epub 2009 Mar 10. PMID: 19277254

Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease.
Thrash JC, Torbett BE, Carson MJ.
Neurochem Res. 2009 Jan;34(1):38-45. Epub 2008 Apr 11. PMID: 18404378

Papenfuss TL, Thrash JC, Danielson PE, Foye PE, Hllbrush BS, Sutcliffe JG, Whitacre CC, Carson MJ.
Induction of Golli-MBP expression in CNS macrophages during acute LPS-induced CNS inflammation and experimental autoimmune encephalomyelitis (EAE).. 2007 Nov 2;7:112-20.
PMID: 17982583 \

Carson MJ, Bilousova TV, Puntambekar SS, Melchior B, Doose JM, Ethell IM.
A rose by any other name? The potential consequences of microglial heterogeneity during CNS health and disease.
Neurotherapeutics. 2007 Oct;4(4):571-9.
PMID: 17920538

Lee JW, Bajwa PJ, Carson MJ, Jeske DR, Cong Y, Elson CO, Lytle C, Straus DS.
Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.
Gastroenterology. 2007 Jul;133(1):108-23. Epub 2007 Apr 11.
PMID: 17631136 [PubMed - indexed for MEDLINE]

Plant SR, Iocca HA, Wang Y, Thrash JC, O'Connor BP, Arnett HA, Fu YX, Carson MJ, Ting JP.
Lymphotoxin beta receptor (Lt betaR): dual roles in demyelination and remyelination and successful therapeutic intervention using Lt betaR-Ig protein.
J Neurosci. 2007 Jul 11;27(28):7429-37.

Carson MJ, Lo DD.
Perspective is everything: An irreverent discussion of CNS-immune system interactions as viewed from different scientific traditions.
Brain Behav Immun. 2007 May;21(4):367-73.

Carson MJ, Doose JM, Melchior B, Schmid CD, Ploix CC.
CNS immune privilege: hiding in plain sight.
Immunol Rev. 2006 Oct;213:48-65.

Plant SR, Wang Y, Vasseur S, Thrash JC, McMahon EJ, Bergstralh DT, Arnett HA, Miller SD, Carson MJ, Iovanna JL, Ting JP.
Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues.
Glia. 2006 Apr 1;53(5):529-37.

NeuroAIDS, drug abuse, and inflammation: building collaborative research activities.
Berman JW, Carson MJ, Chang L, Cox BM, Fox HS, Gonzalez RG, Hanson GR, Hauser KF, Ho WZ, Hong JS, Major EO, Maragos WF, Masliah E, McArthur JC, Miller DB, Nath A, O'Callaghan JP, Persidsky Y, Power C, Rogers TJ, Royal W 3rd.
J Neuroimmune Pharmacol. 2006 Dec;1(4):351-99. Epub 2006 Nov 8.PMID: 18040811

Byram SC, Carson MJ, DeBoy CA, Serpe CJ, Sanders VM, Jones KJ.
CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation.
J Neurosci. 2004 May 5;24(18):4333-9.

Schmid CD, Sautkulis LN, Danielson PE, Cooper J, Hasel KW, Hilbush BS, Sutcliffe JG, Carson MJ.
Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia.
J Neurochem. 2002 Dec;83(6):1309-20.

Boztug K, Carson MJ, Pham-Mitchell N, Asensio VC, DeMartino J, Campbell IL.
Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10.
J Immunol. 2002 Aug 1;169(3):1505-15.

Ploix C, Lo D, Carson MJ.
A ligand for the chemokine receptor CCR7 can influence the homeostatic proliferation of CD4 T cells and progression of autoimmunity.
J Immunol. 2001 Dec 15;167(12):6724-30.

Pagenstecher A, Lassmann S, Carson MJ, Kincaid CL, Stalder AK, Campbell IL.
Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis.
J Immunol. 2000 May 1;164(9):4481-92.

Carson MJ, Reilly CR, Sutcliffe JG, Lo D.
Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells.
Am J Pathol. 1999 Feb;154(2):481-94.

Carson MJ, Sutcliffe JG, Campbell IL.
Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation.
J Neurosci Res. 1999 Jan 1;55(1):127-34.

Stalder AK, Carson MJ, Pagenstecher A, Asensio VC, Kincaid C, Benedict M, Powell HC, Masliah E, Campbell IL.
Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor.
Am J Pathol. 1998 Sep;153(3):767-83.

Carson MJ, Reilly CR, Sutcliffe JG, Lo D.
Mature microglia resemble immature antigen-presenting cells.
Glia. 1998 Jan;22(1):72-85.

Carson MJ, Behringer RR, Brinster RL, McMorris FA.Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice.
Neuron. 1993 Apr;10(4):729-40.

Curras-Collazo

Thu, 23 Apr 2009 15:25:24 -0700

Interests: Neuroendocrinology and medical neuroscience. Specialty areas: neural control of hydromineral balance, autoregulation of magnocellular neuroendocrine cells by vasopressin and actions of endocrine disruptors; mechanisms underlying excitotoxicity and neuroprotection in neurotrauma and stroke injury models.
One main focus of our research is autocontrol of neuroendocrine cells of the supraoptic nucleus of the rat hypothalamus (SON) which produce vasopressin (VP) and oxytocin (OXY), hormones involved in osmoregulation, lactation and parturition as well as cardiovascular function. A recent finding from our lab, modulation of stimulated glutamate release by VP and OXY, suggests that locally released OXY and VP may autoregulate SON activity, in part, by modulating the release of excitatory amino acids from afferent terminals targeting these cells. We are investigating the physiological significance of dendritic signaling by VP and the mechanisms underlying dendritic release of VP including the actions of nitric oxide, VP autoreceptors, pituitary adenylate cyclase activating peptide (PACAP) and glutamate receptors. We have recently discovered a novel role of intra-SON PACAP in controlling VP release stimulated by osmotic activation. Studies are underway that examine the receptor subtypes and signal transduction processes involved in PACAP control over VP release. Other projects examine the mechanisms underlying disruption of osmoregulation and other neuroendocrine processes by the environmental toxins, persistent organic pollutants such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs).
Other studies aim to identify neuroprotective mechanisms relevant to SON viability (these cells are less susceptible to excitotoxic injury (in vitro) and ischemic neuronal death (in vivo) relative to cortical and other central neurons. Our lab has shown that resistance to glutamate-evoked excitotoxicity may be associated with a greater capacity for glutamate clearance and more efficient calcium extrusion and free radical scavenging. In collaboration with investigators at Loma Linda University we have been using brain imaging to describe evolution of brain damage and to predict outcome. More recently, we have been using stem cells to alleviate adverse effects of neurotrauma and other injuries. Our findings may lead eventually to the development of alternative therapies for stroke and neurodegenerative diseases.

Ethell

Thu, 23 Apr 2009 15:24:01 -0700

1: Ethell IM, Ethell DW.
Matrix metalloproteinases in brain development and remodeling:
Synaptic functions and targets.
J Neurosci Res. 2007 Mar 23; [Epub ahead of print]

2: Yang NY, Pasquale EB, Owen LB, Ethell IM.
The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization.
J Biol Chem. 2006 Oct 27;281(43):32574-86. Epub 2006 Aug 31.

3: Bilousova TV, Rusakov DA, Ethell DW, Ethell IM.
Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation.
J Neurochem. 2006 Apr;97(1):44-56. Epub 2006 Mar 3.

4: Shi Y, Ethell IM.
Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization.
J Neurosci. 2006 Feb 8;26(6):1813-22.

5: Hickmott PW, Ethell IM.
Dendritic plasticity in the adult neocortex.
Neuroscientist. 2006 Feb;12(1):16-28. Review.

6: Moeller ML, Shi Y, Reichardt LF, Ethell IM.
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.
J Biol Chem. 2006 Jan 20;281(3):1587-98. Epub 2005 Nov 18.

7: Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M.
GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.
Nat Neurosci. 2005 Jul;8(7):906-15.

8: Ethell IM, Pasquale EB.
Molecular mechanisms of dendritic spine development and remodeling.
Prog Neurobiol. 2005 Feb;75(3):161-205. Epub 2005 Apr 2.

9: Henkemeyer M, Itkis OS, Ngo M, Hickmott PW, Ethell IM.
Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.
J Cell Biol. 2003 Dec 22;163(6):1313-26.

10: Ethell IM, Irie F, Kalo MS, Couchman JR, Pasquale EB, Yamaguchi Y.
EphB/syndecan-2 signaling in dendritic spine morphogenesis.
Neuron. 2001 Sep 27;31(6):1001-13.

11: Miura R, Ethell IM, Yamaguchi Y.
Carbohydrate-protein interactions between HNK-1-reactive sulfoglucuronyl glycolipids and the proteoglycan lectin domain mediate neuronal cell adhesion and neurite outgrowth.
J Neurochem. 2001 Jan;76(2):413-24.

12: Ethell IM, Hagihara K, Miura Y, Irie F, Yamaguchi Y.
Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines.
J Cell Biol. 2000 Oct 2;151(1):53-68.

13:
Gartner A, Shostak Y, Hackel N, Ethell IM, Thoenen H.
Ultrastructural identification of storage compartments and localization of activity-dependent secretion of neurotrophin 6 in hippocampal neurons.
Mol Cell Neurosci. 2000 Mar;15(3):215-34.

14:
Miura R, Aspberg A, Ethell IM, Hagihara K, Schnaar RL, Ruoslahti E, Yamaguchi Y.
The proteoglycan lectin domain binds sulfated cell surface glycolipids and promotes cell adhesion.
J Biol Chem. 1999 Apr 16;274(16):11431-8.

15: Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
poptosis through calcineurin dephosphorylation of BAD.
Science. 1999 Apr 9;284(5412):339-43.

16: Ethell IM, Yamaguchi Y.
Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons.
J Cell Biol. 1999 Feb 8;144(3):575-86.

Fiacco

Thu, 23 Apr 2009 15:20:02 -0700

• Fiacco TA, Agulhon C, McCarthy KD. Sorting out astrocyte physiology from pharmacology. Annu Rev Pharmacol Toxicol. 49: 151-74, 2009.
• Agulhon C, Petravicz J, McMullen AB, Sweger EJ, Minton SK, Taves SR, Casper KB, Fiacco TA, McCarthy KD. What Is the Role of Astrocyte Calcium in Neurophysiology? Neuron 59(6): 932-946, 2008.
• Fiacco TA, Agulhon C. Advances in understanding new roles for astrocytes in the modulation of neuronal activity. Physiology News 72: 18-20, 2008.
• Fiacco TA, Casper K, Agulhon C, Sweger E, Taves S, Minton S, McCarthy KD. Molecular approaches for studying astrocytes. In: Astrocytes in (patho)Physiology of the Nervous System, Springer ( Boston , MA ); Edited by Vladimir Parpura and Phil Haydon, pp. 383-406, 2008.
• Petravicz J, Fiacco TA, McCarthy KD. Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. Journal of Neuroscience 28(19):4967-73, 2008.
• Djukic B, Fiacco TA, McCarthy KD. Astrocyte signaling systems in physiology and pathology. In: Immune and Glial Regulation of Pain, edited by Joyce A. DeLeo, Linda S. Sorkin, and Linda R. Watkins, IASP Press, Seattle, pp.229-247, 2007.
• Fiacco TA, Agulhon C, Taves S, Petravicz J, Casper K, Dong Xinzhong, Chen J, McCarthy KD. Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity. Neuron 54:611-626, 2007.
• Fiacco TA, McCarthy KD. Astrocyte calcium elevations: Properties, propagation, and effects on brain signaling. Glia 54(7):676-690, 2006.
• Fiacco TA, McCarthy KD. Intracellular astrocyte calcium waves in situ increase the frequency of spontaneous AMPA receptor currents in CA1 pyramidal neurons. Journal of Neuroscience 24:722-732, 2004.
• Fiacco TA, Rosene DL, Galler JR, Blatt GJ. Increased density of hippocampal kainate receptors but normal density of NMDA and AMPA receptors in a rat model of prenatal protein malnutrition. Journal of Comparative Neurology 456:350-360, 2003.
• Tonkiss J, Shultz P, Shumsky JS, Fiacco TA, Vincitore M, Rosene DL, and JR Galler. Chlordiazepoxide-induced spatial learning deficits: dose-dependent differences following prenatal malnutrition. Pharmacology, Biochemistry, and Behavior 65(1):105, 1999.