Education

    Ph.D., Cellular and Integrative Physiology, West Virginia University, Morgantown, WV, 2009

    M.S., Exercise Physiology, West Virginia University, Morgantown, WV 2003   

    B.S., Exercise Physiology, West Virginia University, Morgantown, WV 2001

Research Interests

 

    Understanding the physiological effects of healthy aging on the vascular system

    Determining the mechanisms by which exercise training and lifestyle influence vascular

    aging

Full-Length Manuscripts

    Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM. Effects of aging and exercise

    training on eNOS uncoupling in skeletal muscle resistance arterioles. J Physiol 587:

    3885-97, 2009

    Kang LS, Kim SJ, Dominguez JM 2nd, Sindler AL, Dick GM, Muller-Delp JM. Aging

    and muscle fiber type alter K+ channel contributions to the myogenic response in

    skeletal muscle arterioles. J Appl Physiol 107 (2): 389-98, 2009

    Peterson JM, Bryner RW, Sindler A, Frisbee JC, Alway SE. Mitochondrial apoptotic        

    signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is

    reduced with aerobic exercise. J Appl Physiol, 105: 1934-43, 2008

    Spranger J, Verma S, Göhring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman

    SM, Tschöp M, Banks WA.  Adiponectin does not cross the blood-brain barrier but

    modifies cytokine expression of brain endothelial cells. Diabetes, 55: 141-47, 2006

Recent Abstracts

    Moningka NC, Sindler AL, Muller-Delp J, Baylis C. Twelve Weeks of Treadmill Exercise

    Accelerates Age-Dependent Kidney Disease in the Fisher 344 (F344) Male Rat. 

    American Society of Nephrology Conference 2009.

    Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM. Effect of aging and exercise    

    training on eNOS uncoupling and O2- signaling in skeletal muscle arterioles. FASEB J.

    2009 23:608.12.

    Sindler AL, Reyes R, Muller-Delp J. Oxidant Stress is Required for Endothelium-

    Dependent Dilation in Skeletal Muscle Arterioles. The Physiologist Dec 2008 51:p 38.

    Morgan SM, Kang LS, Sindler AL, Kim SJ, Muller-Delp JM. Voltage-gated Potassium

    Channel Regulation of Myogenic Activity Increases with Age in Soleus Muscle

    Arterioles.  Microcirculation Jun 2007, 14; Issue 4/5, p547, VR-44.

    Sindler AL, Kang LS, Dominguez J, Reyes R, Muller-Delp, JM. Effects of Tempol on

    Endothelial-Dependent Vasodilation in Soleus Muscle Arterioles in Response to Age and

    Exercise Training. FASEB J 2007, 21:lb462

    Sindler AL, Morgan SM, Reyes R, Peterson J, Frisbee J, Muller-Delp JM, Bryner R,

    Hileman SM. Chronic Exercise Training Increases Insulin Sensitivity in Obese Zucker

    Rats Potentially Via Hypothalamic Adiponectin Receptor 1.  Medicine and Science in

    Sports and Exercise 2006. 38(11): p. Suppl 1: S39.

Current projects

    Determining the effects of healthy aging and exercise training on large artery endothelial

    function and arterial stiffness

    Reduced inflammatory suppression of endothelial-dependent dilation with habitual

    exercise in older adults

    Effects of sodium nitrite supplementation on endothelial function and arterial stiffness

    Role of AMP-activated kinase on endothelial function and arterial stiffness in older adults

Professional Affiliations

    American Association for the Advancement of Science (AAAS)

    American College of Sports Medicine (ACSM)

    American Physiological Society (APS)